Publications for Sachin Gupte s_gupte@nymc.edu

NYMC School of Medicine
  • Chettimada, S., Joshi, S. R., Dhagia, V., Aiezza II, A., Lincoln, T. M., Gupte, R., . . . Gupte, S. A. (2016). Vascular smooth muscle cell contractile protein expression is increased through PKG-dependent and -independent pathways by G6PD inhibition and deficiency. American Journal of Physiology.Heart and Circulatory Physiology, 311(4), H904-H912. doi:10.1152/ajpheart.00335.2016

  • Joshi, S. R., Dhagia, V., Gairhe, S., Edwards, J. G., McMurtry, I. F., & Gupte, S. A. (2016). MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension. American Journal of Physiology. Heart and Circulatory Physiology, 311(3), H689-H698. doi:10.1152/ajpheart.00264.2016

  • Joshi, S. R., Lakhkar, A., Dhagia, V., Zias, A. L., Jiang, H., Schwartzman, M. L.,. . . Gupte, S. A. (2016). Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice. Pulmonary Circulation, 6(3), 360-368. doi:10.1086/688060

  • Kizub, I. V., Lakhkar, A., Dhagia, V., Joshi, S. R., Wolin, M. S., Schwartzman,  M. L.,. . . Gupte, S. A. (2016). Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: A potential role for 15-HETE and 20-HETE. American Journal of Physiology. Lung Cellular and Molecular Physiology, 310(8), L772-L783. doi:10.1152/ajplung.00377.2015

  • Lakhkar, A., Dhagia, V., Joshi, S. R., Sun, D., Wolin, M. S., Schwartzman, M. L., . . . Gupte, S. A. (2016). 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition. American Journal of Physiology. Heart and Circulatory Physiology, 310(9), H1107-H1117. doi:10.1152/ajpheart.00961.2015

  • Ochi, R., Dhagia, V., Lakhkar, A., Patel, D., Wolin, M. S., & Gupte, S. A. (2016). Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology, 310(9), H1118-H1128. doi:10.1152/ajpheart.00889.2015

  • Ochi, R., Dhagia, V., Patel, D., Wolin, M. S., & Gupte, S. A. (2016). L-type Ca2+ current increase by rotenone, stimulant of mitochondrial superoxide release, in A7r5 arterial smooth muscle cells. effect of dithiothreitol, hydrogen peroxide, tempol and staurosporine. FASEB Journal, 30(Suppl 1), 1224.15. 

  • Ochi, R., Dhagia, V., Patel, D., Wolin, M. S., & Gupte, S. A. (2016). Rotenone, stimulant of superoxide release from mitochondrial complex I, transiently augments L-type calcium current in A7r5 arterial smooth muscle cells. Biophysical Journal, 110(3), 441A. doi:10.1016/j.bpj.2015.11.2375

  • Patel, D., Alhawaj, R., Kelly, M. R., Accarino, J. J., Gupte, S. A., Sun, D., . . . Wolin, M. S. (2016). Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II. American Journal of Physiology. Heart and Circulatory Physiology, 310(11), H1439-H1447. doi:10.1152/ajpheart.00859.2015

  • Chettimada, S., Gupte, R., Rawat, D., Gebb, S. A., McMurtry, I. F., & Gupte, S. A. (2015). Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: Implication in pulmonary hypertension. American Journal of Physiology - Lung Cellular and Molecular Physiology, 308(3), L287-L300. doi:10.1152/ajplung.00229.2014

  • Chettimada, S., Ata, H., Rawat, D. K., Gulati, S., Kahn, A. G., Edwards, J. G., & Gupte, S. A. (2014). Contractile protein expression is upregulated by reactive oxygen species in aorta of Goto-Kakizaki rat. American Journal of Physiology. Heart and Circulatory Physiology, 306(2), H214-224. doi:10.1152/ajpheart.00310.2013

  • Chettimada, S., Joshi, S. R., Al Zoubi, A., Gebb, S. A., McMurtry, I. F., Gupte, R. S., & Gupte, S. A. (2014). Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal. American Journal of Physiology. Lung Cellular and Molecular Physiology, 307(7), L545-556. doi:ajplung.00303.2013

  • Gupte, S., Strother, J., Hodge, J., Gupte, R., & Gulati, S. (2014). Effect of thermal injury on TRPV4 and c-Kit+ stem cells in skin. Journal of Burn Care and Research, 35(Suppl. 1), S207.

  • Joshi, S., Alloosh, M., & Gupte, S. (2014). Glucose-6-phosphate dehydrogenase is involved in regulation of arterial smooth muscle phenotype in metabolic syndrome. FASEB Journal, 28(1 Suppl.), 1076.5.

  • Lakhkar, A., Joshi, S., & Gupte, S. (2014). Regulation of cGMP by glucose-6-phosphate dehydrogenase through PDE5 In coronary artery. FASEB Journal, 28(1 Suppl), 849.2.

  • Ochi, R., Chettimada, S., & Gupte, S. A. (2014). Poly(ethylene glycol)-cholesterol inhibits L-type Ca2+ channel currents and augments voltage-dependent inactivation in A7r5 cells. PLoS One, 9(9), e107049. doi:10.1371/journal.pone.0107049

  • Ochi, R., Chettimada, S., Wolin, M., & Gupte, S. (2014). L-type Ca2+ channel current is controlled by ROS regulated by glucose-6-phosphate dehydrogenase and mitochondrial respiratory chain complex i. FASEB Journal, 28(1 Suppl.), 698.2.

  • Rawat, D. K., Alzoubi, A., Gupte, R., Chettimada, S., Watanabe, M., Kahn, A. G., . . . & Gupte, S. A. (2014). Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure. Hypertension, 64(6), 1266-1274. doi:10.1161/HYPERTENSIONAHA.114.03261

  • Vimercati, C., Qanud, K., Mitacchione, G., Sosnowska, D., Ungvari, Z., Hintze, T. H., . . . Gupte, S. A. (2014). Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart. American Journal of Physiology. Heart and Circulatory Physiology, 306(5), H709-H717. doi:10.1152/ajpheart.00783.2013