Publications for Diane Heck diane_heck@nymc.edu

Composto, G. M., Laskin, J. D., Laskin, D. L., Gerecke, D. R., Casillas, R. P., Heindel, N. D., . . . Heck, D. E. (2016). Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Experimental and Molecular Pathology, 100(3), 522-531. doi:10.1016/j.yexmp.2016.05.008

Jan, Y. H., Richardson, J. R., Baker, A. A., Mishin, V., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2016). Novel approaches to mitigating parathion toxicity: Targeting cytochrome P450-mediated metabolism with menadione. Annals of the New York Academy of Sciences, 1378(1), 80-86. doi:10.1111/nyas.13156

Joseph, L. B., Composto, G. M., & Heck, D. E. (2016). Tissue injury and repair following cutaneous exposure of mice to sulfur mustard. Annals of the New York Academy of Sciences, 1378(1), 118-123. doi:10.1111/nyas.13125

Lacey, C. J., Wohlman, I., Guillon, C., Saxena, J., Fianu-Velgus, C., Aponte, E., . . . Heck, D. E. (2016). Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Annals of the New York Academy of Sciences, 1378(1), 174-179. doi:10.1111/nyas.13177

Malaviya, R., Sunil, V. R., Venosa, A., Vayas, K. N., Businaro, R., Heck, D. E., . . . Laskin, D. L. (2016). Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants. Annals of the New York Academy of Sciences, 1374(1), 168-175. doi:10.1111/nyas.13123

Malaviya, R., Sunil, V. R., Venosa, A., Vayas, K. N., Heck, D. E., Laskin, J. D., & Laskin, D. L. (2016). Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicology Letters, 244, 2-7. doi:10.1016/j.toxlet.2015.10.011

Jan, Y. H., Heck, D. E., Casillas, R. P., Laskin, D. L., & Laskin, J. D. (2015). Thioredoxin cross-linking by nitrogen mustard in lung epithelial cells: Formation of multimeric thioredoxin/thioredoxin reductase complexes and inhibition of disulfide reduction. Chemical Research in Toxicology, 28(11), 2091-2103. doi:10.1021/acs.chemrestox.5b00194

Jan, Y. H., Richardson, J. R., Baker, A. A., Mishin, V., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2015). Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicology and Applied Pharmacology, 288(1), 114-120. doi:10.1016/j.taap.2015.07.023

Saxena, J., Meloni, D., Huang, M. T., Heck, D. E., Laskin, J. D., Heindel, N. D., & Young, S. C. (2015). Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters, 25(23), 5609-5612. doi:10.1016/j.bmcl.2015.10.039

Shakarjian, M. P., Ali, M. S., Veliskova, J., Stanton, P. K., Heck, D. E., & Velisek, L. (2015). Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice. Neurotoxicology, 48, 100-108. doi:10.1016/j.neuro.2015.03.007

Yang, S., Jan, Y. H., Mishin, V., Richardson, J. R., Hossain, M. M., Heindel, N. D., . . . Heck, D. E., (2015). Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. The Journal of Pharmacology and Experimental Therapeutics, 352(3), 529-540. doi:10.1124/jpet.114.221572

Chang, Y. C., Wang, J. D., Hahn, R. A., Gordon, M. K., Joseph, L. B., Heck, D. E., . . . Gerecke, D. R. (2014). Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicology and Applied Pharmacology, 15(2), 236-244. doi:S0041-008X(14)00276-2

Guillon, C. D., Wisnoski, D. D., Saxena, J., Heindel, N. D., Heck, D. E., Wolff, D. J., & Laskin, J. D. (2014). Nw-Nitro-Nw -substituted guanidines: A simple class of nitric oxide synthase inhibitors. Modern Research in Inflammation, 3, 48-58. doi:10.4236/mri.2014.32006

Heck, D. E., Joseph, L. B., & Kim, H. D. (2014). Dermal toxicity biomarkers. In Gupta, R. C. (Ed.), Biomarkers in Toxicology (pp. 309-316). Amsterdam, The Netherlands: Elsevier/Academic Press.  doi:10.1016/B978-0-12-404630-6.00018-X

Jan, Y. H., Dragomir, A.C., Gardner, C., Heck, D., Laskin, D., & Laskin, J. (2014). Targeting hepatic thioredoxin reductase by the acetaminophen metabolite N-acetyl-p-benzoquinone. FASEB Journal, 28(1 Suppl.), 844.15.

Jan, Y. H., Heck, D. E., Dragomir, A. C., Gardner, C. R., Laskin, D. L., & Laskin, J. D. (2014). Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chemical Research in Toxicology, 27(5), 882-894. doi:10.1021/tx5000443

Jan, Y. H., Heck, D. E., Malaviya, R., Casillas, R. P., Laskin, D. L., & Laskin, J. D. (2014). Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: Selective inhibition of disulfide reduction but not redox cycling. Chemical Research in Toxicology, 27(1), 61-75. doi:10.1021/tx400329a

Joseph, L. B., Heck, D. E., Cervelli, J. A., Composto, G. M., Babin, M. C., Casillas, R. P., . . . Laskin, J. D. (2014). Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Experimental and Molecular Pathology, 96(3), 316-327. doi:10.1016/j.yexmp.2014.03.002

Mishin, V., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2014). Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicological Sciences, 141(2), 344-352.  doi:10.1093/toxsci/kfu133

Shakarjian, M. P., Ali, M., Heck, D., Veliskova, J., & Velisek, L. (2014). Combined treatment with diazepam and MK-801 provide enhanced protection from tetramethylenedisulfotetramine-induced seizures and lethality. FASEB Journal, 28(1 Suppl.), 1143.14.

Zheng, R., Dragomir, A. C., Mishin, V., Richardson, J. R., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2014). Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicology and Applied Pharmacology, 279(1), 43-52. doi:10.1016/j.taap.2014.04.026

Zheng, R., Heck, D. E., Mishin, V., Black, A. T., Shakarjian, M. P., Kong, A. N., . . . Laskin, J. D. (2014). Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicology and Applied Pharmacology, 275(2), 113-121. doi:10.1016/j.taap.2014.01.001

Yang, S., Jan, Y. H., Gray, J. P., Mishin, V., Heck, D. E., Laskin, D. L., & Laskin, J. D. (2013). Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. Journal of Biological Chemistry, 288(26), 19221-19237. doi:10.1074/jbc.M112.402164

Zheng, R., Po, I., Mishin, V., Black, A. T., Heck, D. E., Laskin, D. L., . . . Laskin, J. D. (2013). The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicology and Applied Pharmacology, 272(2), 345-355. doi:10.1016/j.taap.2013.06.025