Publications for Miriam Gochin miriam.gochin@tu.edu
Chu, S., Zhou, G., & Gochin, M. (2017). Evaluation of ligand-based NMR screening methods to characterize small molecule binding to HIV-1 glycoprotein-41. Organic & Biomolecular Chemistry, 15(24), 5210-5219. This material can be found here.
Sofiyev, V., Kaur, H., Snyder, B. A., Hogan, P. A., Ptak, R. G., Hwang, P., & Gochin, M. (2017). Enhanced potency of bivalent small molecule gp41 inhibitors, Bioorganic & Medicinal Chemistry, 25(1), 408-420. doi:10.1016/j.bmc.2016.11.010
Lam, K., Caccavello, R., Mustafa, A., Wills, R., Lehrner, L., Gugliucci, A., & Gochin, M. (2016). 1H NMR spectral analysis of hemodialysis patients. Journal of the American Osteopathic Association, 116(9), e45. This material can be found here.
Allen, W. J., Yi, H. A., Gochin, M., Jacobs, A., & Rizzo, R. C. (2015). Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation. Bioorganic & Medicinal Chemistry Letters, 25(14), 2853-2859. doi:10.1016/j.bmcl.2015.04.067
Chu, S., Kaur, H., Nemati, A., Walsh, J. D., Partida, V., Zhang, S. Q., & Gochin, M. (2015). Swapped-domain constructs of the glycoprotein-41 ectodomain are potent inhibitors of HIV infection. ACS Chemical Biology, 10(5), 1247-1257. doi:10.1021/cb501021j
Ng, M., Keppler, D., & Gochin, M. (2015). Identification of biomarkers in etoposide-treated cells. Journal of the American Osteopathic Association, 115(12), e31-e32. This material can be found here.
Partida, V., Park, J. D., Chu, S., Gochin, M., & Nemati, A. (2015). Reverse hairpin constructs of gp41 as fusion inhibitors of HIV infection. Journal of the American Osteopathic Association, 115(12), e28-e29. This material can be found here.
Walsh, J. D., Chu, S., Zhang, S. Q., & Gochin, M. (2015). Design and characterization of swapped-domain constructs of HIV-1 glycoprotein-41 as receptors for drug discovery. Protein Engineering Design and Selection, 28(4), 107-116. doi:10.1093/protein/gzv006
Holden, P. M., Allen, W. J., Gochin, M., & Rizzo, R. C. (2014). Strategies for lead discovery: Application of footprint similarity targeting HIVgp41. Bioorganic and Medicinal Chemistry, 22(1), 651-661.
Zhou, G., Sofiyev, V., Kaur, H., Snyder, B. A., Mankowski, M. K., Hogan, P. A., . . . Gochin, M. (2014). Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41. Journal of Medicinal Chemistry, 57(12), 5270–5281. doi:10.1021/jm500344y
Chu, S., & Gochin, M. (2013). Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching. Bioorganic and Medicinal Chemistry Letters, 23(18), 5114-5118. doi:10.1016/j.bmcl.2013.07.026
Gochin, M., Whitby, L. R., Phillips, A. H., & Boger, D. L. (2013). NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. Journal of Computer-Aided Molecular Design, 27(7), 569-582. doi:10.1007/s10822-013-9662-6
Gochin, M. (2012). A suite of modular fluorescence assays interrogate the human immunodeficiency virus Glycoprotein-41 coiled coil and assist in determining binding mechanism of low molecular weight fusion inhibitors. Assay and Drug Development Technologies, 10(5), 407-416. doi:10.1089/adt.2012.464
Holden, P. M., Kaur, H., Goyal, R., Gochin, M., & Rizzo, R. C. (2012). Footprint-based identification of viral entry inhibitors targeting HIVgp41. Bioorganic and Medicinal Chemistry Letters, 22(8), 3011-3016. doi:10.1016/j.bmcl.2012.02.017
Whitby, L. R., Boyle, K. E., Cai, L., Yu, X., Gochin, M., & Boger, D. L. (2012). Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library. Bioorganic and Medicinal Chemistry Letters, 22(8), 2861-2865. doi:10.1016/j.bmcl.2012.02.062
Cai, L., Gochin, M., & Liu, K. (2011). A facile surfactant critical micelle concentration determination. Chemical Communications, 47(19), 5527-5529. This material can be found here.
Cai, L., Gochin, M., & Liu, K. (2011). Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design. Current Topics in Medicinal Chemistry, 11(24), 2959-2984. This material can be found here.
Gochin, M. (2011). Hot topic: Lipophilic and amphiphilic interactions in glycoprotein 41: targets for therapy [Editorial]. Current Topics in Medicinal Chemistry, 11(24), 2945-2946. This material can be found here.
Gochin, M., & Zhou, G. (2011). Amphipathic properties of HIV-1 gp41 fusion inhibitors. Current Topics in Medicinal Chemistry, 11(24), 3022-3032. This material can be found here.
Gochin, M., & Zhou, G. (2011). U.S. Patent No. 8,455,516. Washington, DC: U.S. Patent and Trademark Office.
Gochin, M., Zhou, G., & Phillips, A. H. (2011). Paramagnetic relaxation assisted docking of a small indole compound in the HIV-1 gp41 hydrophobic pocket. ACS Chemical Biology, 6(3), 267-274. This material can be found here.
Zhou, G., Wu, D., Snyder, B., Ptak, R. G., Kaur, H., & Gochin, M. (2011). Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 Glycoprotein-41. Journal of Medicinal Chemistry, 54(20), 7220–7231.
Zhou, G., Wu, D., Hermel, E., Balogh, E., & Gochin, M. (2010). Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41. Bioorganic & Medicinal Chemistry Letters, 20(5), 1500-1503. This material can be found here.
Balogh, E., Wu, D., Zhou, G., & Gochin, M. (2009). NMR second site screening for structure determination of ligands bound in the hydrophobic pocket of HIV-1 gp41. Journal of the American Chemical Society, 131(8), 2821–2823. doi: 10.1021/ja8094558 This material can be found here.
Cai, L., Balogh, E., & Gochin, M. (2009). Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors. Antimicrobial Agents and Chemotherapy, 53(6), 2444-2449. doi: 10.1128/AAC.00150-09 This material can be found here.
